INTRANASAL DELIVERY OF A CHIMPANZEE ADENOVIRUS VECTOR EXPRESSING A PRE-FUSION SPIKE (BV-ADCOV-1) PROTECTS GOLDEN SYRIAN HAMSTERS AGAINST SARS-COV-2 INFECTION

Intranasal delivery of a chimpanzee adenovirus vector expressing a pre-fusion spike (BV-AdCoV-1) protects golden Syrian hamsters against SARS-CoV-2 infection

We evaluated the immunogenicity and protective ability of a Toilet Seat Covers chimpanzee replication-deficient adenovirus vectored COVID-19 vaccine (BV-AdCoV-1) expressing a stabilized pre-fusion SARS-CoV-2 spike glycoprotein in golden Syrian hamsters.Intranasal administration of BV-AdCoV-1 elicited strong humoral and cellular immunity in the anim

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